2009 Gastrointestinal Oncology Conference Review

2009 Gastrointestinal Oncology Conference October 1-3, 2009 Please click on abstract title to review abstract PDF file (opens in a new window).
Session 1: Esophageal Cancer
	Changing Epidemiology and the Role of Combined Modality Therapy David H. Ilson, MD, PhD
	Oncologic Indications for Esophageal-Sparing Surgery in Early-Stage Adenocarcinoma Nabil Rizk, MD
	Hedgehog Signaling—Gli2 and Its Influence in Squamous Esophageal Cancer Kanagavel Manickavasagam, Soorya Rao, Dipanksha Dutta, Meera Govindarajan, Asmita Chandramohan, Servarayan Murugesan Chandramohan
	Neoadjuvant Paclitaxel Poliglumex (PPX), Cisplatin, and Radiation (RT) for Esophageal Cancer T. Ng, J. Fontaine, T. Dipetrillo, M. Suntharalingam, N. Horiba, N. Oldenburg, B. Oconnor, K. Perez, A. Birnbaum, R. Battafarano, W. Burrows, H. Safran
	Neoadjuvant Paclitaxel Poliglumex (PPX), Cisplatin, and Radiation (RT) for Esophageal Cancer T. Ng, J. Fontaine, T. Dipetrillo, M. Suntharalingam, N. Horiba, N. Oldenburg, B. Oconnor, K. Perez, A. Birnbaum, R. Battafarano, W. Burrows, H. Safran
	Safety of Minimally Invasive Esophagectomy (MIE) After Neoadjuvant Chemoradiotherapy and as Primary Resection at a Non-University Tertiary Care Center (NUTCC) Amit Khithani, MBBS; Naresh Ahuja, MD; Joshua Barton, MD; John Jay, MD; D. Rohan Jeyarajah, MD Methodist Dallas Medical Center, Dallas, TX

Session 2: Pancreatic Cancer
	A Novel Small Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In Vivo C.R. Ireson, K.B. Harikumar, A.B. Kunnumakkara, A. Deorukhkar, Z. Tong, S. Jamieson, R.Sutherland, T. Raynham, M. Charles, A. Bagherzadeh, M. Farooq, D. Maru, P.Diagaradjane, N. Ochi, Y. Matsuo, S. Krishnan, J. Gelovani, B.B. Aggarwal, S. Guha
	Phase II Study of Imatinib Mesylate and Gemcitabine for First-line Treatment of Metastatic Pancreatic Cancer Rebecca A. Moss, MD, Dirk Moore, PhD, Mary F. Mulchahy, MD, Kenneth Nahum, DO, Hui Li, MS, Katen Moore, RN, APN-C, AOCN, Jane Fischer, RN, OCN, Srivani Konduri, Henry Durivage, PharmD, Elizabeth Poplin, MD
	Systemic Delivery of Liposome-Incorporated Adrenomedullin Receptor (ADMR) Small Interfering RNA Against Tumor and Its Microenvironment Reduced Pancreatic Tumor Growth Vijaya Ramachandran, Thiruvengadam Arumugam, Robert Langley, Rosa F. Hwang, Pablo Vivas-Mejia, Anil K. Sood, Gabriel Lopez-Berestein, Craig D. Logsdon

Session 3: Advanced Colorectal Cancer
	Treatment of Patients With Incurable Colorectal Cancer Leonard Saltz, MD
	Curable Metastatic Colorectal Cancer Howard S. Hochster, MD
	Randomized Phase 3 Study of Panitumumab With FOLFOX4 Compared to FOLFOX4 Alone as 1st-line Treatment (tx) for Metastatic Colorectal Cancer (mCRC): The PRIME Trial J.Y. Douillard, S. Siena, J. Cassidy, J. Tabernero, R. Burkes, M.E. Barugel, Y. Humblet, D. Cunningham, M. Wolf, J. Gansert
	Randomized Phase 3 Study of Panitumumab With FOLFIRI vs. FOLFIRI Alone as Second-Line Treatment in Patients With Metastatic Colorectal Cancer M. Ducreux, T. Price, Y. Hotko, A. Cervantes, T. André, E. Chan, F. Lordick, A. Rong, J. Gansert, M. Peeters
	Baseline Quality of Life Is a Strong and Independent Prognostic Factor for Overall Survival in Metastatic Colorectal Cancer J. Hubbard, A. Grothey, M. Campbell, P. Novotny, D.J. Sargent, J. Sloan, R.M. Goldberg

Session 4: Hepatobiliary Cancer
	Radiation Therapy for Intrahepatic Cholangiocarcinoma Waqar Haque, Prajnan Das, Milind Javle, Ahmed Kaseb, Steven A. Curley, Jean-Nicolas Vauthey, Eddie K. Abdalla, Marc E. Delclos, Sunil Krishnan, Christopher H. Crane
	Association of Gallbladder Polyp Size With Obesity and With Malignant Potential Seung Beom Lee, You Na Son, Choon Ok Kim, Hee Cheol Kang, Chung Hyun Choi
	Post-Transplant Recurrence of Hepatocellular Carcinoma and Elevated NLR Tarun Rustagi, MD

Session 5: Emerging Science
	Signaling Pathways of Survival—What Can They Teach Us? Peter K. Vogt

Session 6: Adjuvant Colon Cancer
	Fiber as Protective Factor for Colon Polyps Yessenia M. Tantamango, MD, MPH, DrPHc, Synnove F. Knutsen, MD, MPH, PhD, Joan Sabate, MD, MPH, DrPH

Session 7: Gastric Cancer
	Molecular Biology: East and West Ju-Seog Lee
	Gastric Cancer Surgery: East and West Sung Hoon Noh, MD, PhD
	Advanced Gastric Cancer: An Update Al B. Benson III, MD, FACP
	Effects of Genetic Polymorphisms of Thymidylate Synthase (TS) and Methylenetetrahydrofolate Reductase (MTHFR) Along With Folate Intake on Clinical Outcome of Gastric Cancer Patients Treated With Fluorouracil-Based Chemotherapy Kohei Shitara, Keitaro Matsuo, Tomoya Yokota, Daisuke Takahari, Takashi Ura, Akira Sawaki, Hiroki Kawai, Seiji Ito, Kazuo Tajima, Kei Muro, Hideo Tanaka
	Prognostic Value of Preoperative Clinical Staging Assessed by Computed Tomography in Resectable Gastric Cancer Patients: A Viewpoint in the Era of Preoperative Treatment Sook Ryun Park, Min Ju Kim, Keun Won Ryu, Jun Ho Lee, Jong Seok Lee, Byung-Ho Nam, Il Ju Choi, Young Lan Park, Young-Woo Kim
	Phase II Study of Weekly Paclitaxel as Third-Line Chemotherapy for Advanced or Recurrent Gastric Cancer (OGSG0602) Takayuki Kii
	Liposome-Formulated siRNA Against Msi1 and Docetaxel Treatment in an Animal Model of Advanced Gastric Adenocarcinoma Eradicates Cancer Stem Cells and Metastasis J. Giannios

Session 8: Rectal Cancer
	Prognostic Factors for Rectal Cancer and Anal Cancer Prajnan Das, MD, MS, MPH
	Current Approaches to Localized Rectal Cancer—T1-T2 Lesions and the Trans-Anal Approach Lisa Kachnic, MD
	Low Lying Rectal Cancer With Anal Canal Involvement: Abdominoperineal or Low Anterior Resection After Neoadjuvant Chemoradiotherapy Ly Do

Abstracts Selected for Poster Presentations
(note presenting authors appear in bold)
Esophageal Cancer
	Concurrent Docetaxel-Based Chemoradiotherapy in Squamous Cell Esophageal Cancer Rodica Anghel, Laurentia Minea, Xenia Bacinschi, Irina Isacu, Alin Tarlea
	Esophageal Cancer: Retrospective Analysis of a Decade-Long Single-Institution Experience Hong W. Chin, MD, and Michael Baumann
	The Influence of Pretreatment Body Mass Index on Long-Term Prognosis of Patients With Esophageal Carcinoma After Surgery Yuki Hayashi, Arlene M. Correa, Wayne L. Hofstetter, Ara A. Vaporciyan, David C. Rice, Garrett L. Walsh, Reza J. Mehran, Stephen G. Swisher, and Jaffer A. Ajani
	In Patients with Clinical T2N0M0 Esophageal Cancer, Surgery First or Preoperative Chemoradiotherapy? Panteleimon Kountourakis, Arlene M. Correa, Yuki Hayashi, Wayne L. Hofstetter, Ritsuko Komaki, Ara A. Vaporciyan, David C. Rice, Garrett L. Walsh, Jeffrey H. Lee, Manoop S. Bhutani, William A. Ross, Zhongxing Liao, Stephen G. Swisher, and Jaffer A. Ajani
Pancreatic Cancer
	Clinical Profile of Patients With Periampullary Carcinoma A. Chauhan, C.G. Pai, V.S. Binu
	Long-Term Survival in Metastatic Pancreatic Adenocarcinoma and Cholangiocarcinoma Can Be Achieved With “Metronomic Dosing” of Paclitaxel/Oxaliplatin/Leucovorin/5-Fluorouracil (POLF) and Possibly Other Chemotherapy Regimens Ben M. Chue
	Change in Renal Function as Measured by Technetium99m MAG-3 Scintigraphy and Biochemical Endpoints Following Abdominal Chemoradiation for Gastrointestinal Malignancies Kilian Salerno May, MD; Rameela Chandrasekhar, MA; Harish K. Malhotra, PhD; Richard C. Russo, CMD; Leayn Flaherty, BS; Gregory E. Wilding, PhD; Nikhil I. Khushalani, MD; Gary Y. Yang, MD
	CXC-Chemokine/CXCR2 Biologic Axis Promotes Angiogenesis In Vitro and In Vivo in Pancreatic Cancer Yoichi Matsuo, Massimo Raimondo, Timothy A. Woodward, Michael B. Wallace, Kanwar R Gill, Nobuo Och1, Zhimin Tong, Robert M. Strieter, Robert M. Hoffman, Sushovan Guha
	Use of CA 19-9 and CEA to Predict Operability and Survival in Patients With Pancreatic Malignancies Jay Mehta, Ramkrishna Prabhu, Chetan Kantharia, Avinash Supe
	Can CXC-Chemokines and Lipocalin 2 in Exocrine Pancreatic Secretions Distinguish Chronic Pancreatitis From Pancreatic Cancer? N. Ochi, M. Raimondo, K. Gill2, M.B. Wallace, T.A. Woodward, Y. Matsuo, S. Guha
	Gastric Large Cell Neuroendocrine Carcinoma Tarun Rustagi, MD, Todd J. Alekshun, MD
	Zollinger-Ellison Syndrome with Subsequent Association of Insulinoma Tarun Rustagi, M1, Robert D. Siegel, MD
	Adjuvant Therapy Does Not Improve Survival of Ampullary Carcinoma Patients Avinash Kumar Tank, Rajneesh Kumar Singh, Anand Prakash, Anu Behari, Ashok Kumar, Rajan Saxena, Vinay Kumar Kapoor
	Intensity-Modulated Radiation Therapy Improves the Toxicity Profile of Concurrent Chemoradiation for Upper Abdominal Cancers Susannah Yovino, Matthew Poppe, Salma Jabbour, Vera David, Michael Garofalo, Naimesh Pandya, Richard Alexander, Nader Hanna, William F. Regine
Advanced Colorectal Cancer
	Cost-Effective Chemotherapy Treatment for Advanced Colorectal Cancer Minsig Choi, MD, Mike Griswold, PhD, Tawfiq Khansur, MD
	Inhibition of Epithelial Mesenchymal Transition (EMT) With Immunochemogene Treatment in Metastatic Colorectal Cancer John Giannios, Emmanuel Michailakis, John Papanikolaou, Nick Alexandropoulos
	*Detection of K-ras* Mutation in Serum DNA of Colon Cancer Patients** Jin Kim, Sung Soo Park, Hyun-Jung Joo, Jae Sook Sung, Kyong Hwa Park, Yeul Hong Kim
	Cross-talk Between Notch and Akt/mTOR Signaling in Colon Cancer Cells Srinivas Koduru, Raj Kumar, Sowmyalakshmi Srinivasan, Chendil Damodaran
	Cytotoxicity and Pharmacokinetics of Four Platinum Salts in Human Colon Carcinoma Cell-Line HCT116 Thititip Tippayamontri, Rami Kotb, Léon Sanche, Benoit Paquette
Hepatobiliary Cancer
	Liver Transplant for Hepatocellular Carcinoma: Younger Age, Tumor Grade and Pathologic Complete Response to Pre-Transplant Treatment at Time of Surgery Are Best Predictors of Disease-Free Survival Putao Cen, Alan Cohen, Fatima Anderson, Bob Saggi, Michael Fallon, Victor Machicao, Moises Nevah Rubin, Voon Liaw, Luis Mieles
	Intraluminal Brachytherapy as a Palliative Treatment for Inoperable Klatskin Tumor: Case Report A. Chauhan, P.U. Saxena, S. Charudutt
	Temporal Stability of Percutaneously Implanted Coiled Wire Fiducial Markers for Liver IGRT Valerie M. Gironda, MD; Geoffrey Zhang, PhD; Mark Russell, MS; Vladimir Feygelman, PhD; Junsung Choi, MD; Sarah E. Hoffe, MD
	Transcriptional Regulation of Stat3 by TGF-b Signaling in Liver Cancer Cells Ling Lin1, Kyi Soe, Zhixing Yao, Wilma S. Jogunoori, Lopa Mishra, Aiwu Ruth He
	Ruptured Adenosquamous Cell Carcinoma of the Gallbladder Tarun Rustagi, MD, Mridula Rai, MD, Mohanakrishnan Menon, MD
Adjuvant Colon Cancer
	Retrospective Assessment of an Alternative Adjuvant Treatment of Colon Cancer: Oxaliplatin Plus Weekly Bolus 5-Fluorouracil/ Leucovorin Esther Uña Cidón, Francisco López-Lara
Gastric Cancer
	Gene-Modified Cellular Vaccine (GMCV) Transfected with Lipid-Cation Hsp70 Activates Innate and Adaptive Immunity in Primary and Metastatic Gastric Cancer Cells J. Giannios, E. Michailakis, S. Delis
	Stem Cell Therapy With Mesenchymal Stem Cells Induces Apoptosis in Advanced Gastric Adenocarcinoma, and Docetaxel Inhibits Epithelial Mesenchymal Transition J. Giannios, E. Michailakis, J. Papanikolaou, N. Alexandropulos
	Prognosis of Curatively Resected T4 Gastric Cancer: Significance of Combined Resection Jong-Inn Lee, Jae-Seok Min, Sung-Ho Jin, Jae-Hwan Lee, 1Hye-Jin Kang, 2Sun-Hoo Park, Ho-Yoon Bang
	*Conditional Inactivation of Klf4Gene in Distinct Cell Population of Stomach Mucosa Renders Mice Susceptible to Gastric Carcinogenesis* Qiang Li, Li Wang, Zhiliang Jia, Daoyan Wei, Xiangdong Le, Keping Xie
	Preoperative Computed Tomography in Gastric Cancer: Does It Work? Esther Uña, Isabel Jiménez
	Nutritional Status After Total Gastrectomy for Gastric Cancer Esther Uña Cidón
	Evaluation of Anti-Cancer Drugs in Advanced and Metastatic Non-Colorectal Gastrointestinal Cancers Helmy M. Guirgis, MD, PhD
	*Nigella sativa* L Oil Ameliorates Methotrexate-Induced Intestinal Toxicity Rania M. Labib, Osama A. Badary, Hafez F. Hafez, and Mostafa A.M. Abd El-Hamid
	Paraneoplastic Cerebellar Degeneration in Patients With Gastrointestinal Malignancies Nishant Tageja, MD, Jason Valent, MD, Sachin Gupta, MD