Promoting Excellence in Education, Research,
and Patient Care in the Rapidly Evolving
Management of Gastrointestinal Cancer
International Society of
Gastrointestinal Oncology
isgioEstablished 2003

2009 Gastrointestinal Oncology Conference Review

2009 Gastrointestinal Oncology Conference
October 1-3, 2009

Please click on abstract title to review abstract PDF file (opens in a new window).

Session 1: Esophageal Cancer
  Changing Epidemiology and the Role of Combined Modality Therapy
David H. Ilson, MD, PhD
  Oncologic Indications for Esophageal-Sparing Surgery in Early-Stage Adenocarcinoma
Nabil Rizk, MD

Hedgehog Signaling—Gli2 and Its Influence in Squamous Esophageal Cancer
Kanagavel Manickavasagam, Soorya Rao, Dipanksha Dutta, Meera Govindarajan, Asmita
Chandramohan, Servarayan Murugesan Chandramohan


Neoadjuvant Paclitaxel Poliglumex (PPX), Cisplatin, and Radiation (RT) for Esophageal Cancer
T. Ng, J. Fontaine, T. Dipetrillo, M. Suntharalingam, N. Horiba, N. Oldenburg, B. Oconnor,
K. Perez, A. Birnbaum, R. Battafarano, W. Burrows, H. Safran


Neoadjuvant Paclitaxel Poliglumex (PPX), Cisplatin, and Radiation (RT) for Esophageal Cancer
T. Ng, J. Fontaine, T. Dipetrillo, M. Suntharalingam, N. Horiba, N. Oldenburg, B. Oconnor,
K. Perez, A. Birnbaum, R. Battafarano, W. Burrows, H. Safran


Safety of Minimally Invasive Esophagectomy (MIE) After Neoadjuvant Chemoradiotherapy and as Primary Resection at a Non-University Tertiary Care Center (NUTCC)
Amit Khithani, MBBS; Naresh Ahuja, MD; Joshua Barton, MD; John Jay, MD; D. Rohan Jeyarajah, MD
Methodist Dallas Medical Center, Dallas, TX

Session 2: Pancreatic Cancer
  A Novel Small Molecule Inhibitor of Protein Kinase D Blocks Pancreatic Cancer Growth In Vivo
C.R. Ireson, K.B. Harikumar, A.B. Kunnumakkara, A. Deorukhkar, Z. Tong, S. Jamieson, R.Sutherland, T. Raynham, M. Charles, A. Bagherzadeh, M. Farooq, D. Maru, P.Diagaradjane, N. Ochi, Y. Matsuo, S. Krishnan, J. Gelovani, B.B. Aggarwal, S. Guha
  Phase II Study of Imatinib Mesylate and Gemcitabine for First-line Treatment of Metastatic Pancreatic Cancer
Rebecca A. Moss, MD, Dirk Moore, PhD, Mary F. Mulchahy, MD, Kenneth Nahum, DO, Hui Li, MS, Katen Moore, RN, APN-C, AOCN, Jane Fischer, RN, OCN, Srivani Konduri, Henry Durivage, PharmD, Elizabeth Poplin, MD
  Systemic Delivery of Liposome-Incorporated Adrenomedullin Receptor (ADMR) Small Interfering RNA Against Tumor and Its Microenvironment Reduced Pancreatic Tumor Growth
Vijaya Ramachandran, Thiruvengadam Arumugam, Robert Langley, Rosa F. Hwang, Pablo Vivas-Mejia, Anil K. Sood, Gabriel Lopez-Berestein, Craig D. Logsdon
Session 3: Advanced Colorectal Cancer

Treatment of Patients With Incurable Colorectal Cancer
Leonard Saltz, MD


Curable Metastatic Colorectal Cancer
Howard S. Hochster, MD


Randomized Phase 3 Study of Panitumumab With FOLFOX4 Compared to FOLFOX4 Alone as 1st-line Treatment (tx) for Metastatic Colorectal Cancer (mCRC): The PRIME Trial
J.Y. Douillard, S. Siena, J. Cassidy, J. Tabernero, R. Burkes, M.E. Barugel, Y. Humblet, D. Cunningham, M. Wolf, J. Gansert

  Randomized Phase 3 Study of Panitumumab With FOLFIRI vs. FOLFIRI Alone as Second-Line Treatment in Patients With Metastatic Colorectal Cancer
M. Ducreux, T. Price, Y. Hotko, A. Cervantes, T. André, E. Chan, F. Lordick, A. Rong, J. Gansert, M. Peeters
  Baseline Quality of Life Is a Strong and Independent Prognostic Factor for Overall Survival in Metastatic Colorectal Cancer
J. Hubbard, A. Grothey, M. Campbell, P. Novotny, D.J. Sargent, J. Sloan, R.M. Goldberg
Session 4: Hepatobiliary Cancer

Radiation Therapy for Intrahepatic Cholangiocarcinoma
Waqar Haque, Prajnan Das, Milind Javle, Ahmed Kaseb, Steven A. Curley, Jean-Nicolas Vauthey, Eddie K. Abdalla,
Marc E. Delclos, Sunil Krishnan, Christopher H. Crane


Association of Gallbladder Polyp Size With Obesity and With Malignant Potential
Seung Beom Lee, You Na Son, Choon Ok Kim, Hee Cheol Kang, Chung Hyun Choi


Post-Transplant Recurrence of Hepatocellular Carcinoma and Elevated NLR
Tarun Rustagi, MD

Session 5: Emerging Science

Signaling Pathways of Survival—What Can They Teach Us?
Peter K. Vogt

Session 6: Adjuvant Colon Cancer

Fiber as Protective Factor for Colon Polyps
Yessenia M. Tantamango, MD, MPH, DrPHc, Synnove F. Knutsen, MD, MPH, PhD, Joan Sabate, MD, MPH, DrPH

Session 7: Gastric Cancer

Molecular Biology: East and West
Ju-Seog Lee


Gastric Cancer Surgery: East and West
Sung Hoon Noh, MD, PhD


Advanced Gastric Cancer: An Update
Al B. Benson III, MD, FACP


Effects of Genetic Polymorphisms of Thymidylate Synthase (TS) and Methylenetetrahydrofolate Reductase (MTHFR) Along With Folate Intake on Clinical Outcome of Gastric Cancer Patients Treated With Fluorouracil-Based Chemotherapy
Kohei Shitara, Keitaro Matsuo, Tomoya Yokota, Daisuke Takahari, Takashi Ura, Akira Sawaki, Hiroki Kawai, Seiji Ito,
Kazuo Tajima, Kei Muro, Hideo Tanaka


Prognostic Value of Preoperative Clinical Staging Assessed by Computed Tomography in Resectable Gastric Cancer Patients: A Viewpoint in the Era of Preoperative Treatment
Sook Ryun Park, Min Ju Kim, Keun Won Ryu, Jun Ho Lee, Jong Seok Lee, Byung-Ho Nam, Il Ju Choi, Young Lan Park, Young-Woo Kim


Phase II Study of Weekly Paclitaxel as Third-Line Chemotherapy for Advanced or Recurrent Gastric Cancer (OGSG0602)
Takayuki Kii


Liposome-Formulated siRNA Against Msi1 and Docetaxel Treatment in an Animal Model of Advanced Gastric Adenocarcinoma Eradicates Cancer Stem Cells and Metastasis
J. Giannios

Session 8: Rectal Cancer

Prognostic Factors for Rectal Cancer and Anal Cancer
Prajnan Das, MD, MS, MPH


Current Approaches to Localized Rectal Cancer—T1-T2 Lesions and the Trans-Anal Approach
Lisa Kachnic, MD


Low Lying Rectal Cancer With Anal Canal Involvement: Abdominoperineal or Low Anterior Resection After Neoadjuvant Chemoradiotherapy
Ly Do

Abstracts Selected for Poster Presentations
(note presenting authors appear in bold)
Esophageal Cancer

Concurrent Docetaxel-Based Chemoradiotherapy in Squamous Cell Esophageal Cancer
Rodica Anghel, Laurentia Minea, Xenia Bacinschi, Irina Isacu, Alin Tarlea


Esophageal Cancer: Retrospective Analysis of a Decade-Long Single-Institution Experience
Hong W. Chin, MD, and Michael Baumann


The Influence of Pretreatment Body Mass Index on Long-Term Prognosis of Patients With Esophageal Carcinoma After Surgery
Yuki Hayashi, Arlene M. Correa, Wayne L. Hofstetter, Ara A. Vaporciyan, David C. Rice, Garrett L. Walsh,
Reza J. Mehran, Stephen G. Swisher, and Jaffer A. Ajani


In Patients with Clinical T2N0M0 Esophageal Cancer, Surgery First or Preoperative Chemoradiotherapy?
Panteleimon Kountourakis, Arlene M. Correa, Yuki Hayashi, Wayne L. Hofstetter, Ritsuko Komaki, Ara A. Vaporciyan,
David C. Rice, Garrett L. Walsh, Jeffrey H. Lee, Manoop S. Bhutani, William A. Ross, Zhongxing Liao,
Stephen G. Swisher, and Jaffer A. Ajani

Pancreatic Cancer

Clinical Profile of Patients With Periampullary Carcinoma
A. Chauhan, C.G. Pai, V.S. Binu

  Long-Term Survival in Metastatic Pancreatic Adenocarcinoma and Cholangiocarcinoma Can Be Achieved With “Metronomic Dosing” of Paclitaxel/Oxaliplatin/Leucovorin/5-Fluorouracil (POLF) and Possibly Other Chemotherapy Regimens
Ben M. Chue

Change in Renal Function as Measured by Technetium99m MAG-3 Scintigraphy and Biochemical Endpoints Following Abdominal Chemoradiation for Gastrointestinal Malignancies
Kilian Salerno May, MD; Rameela Chandrasekhar, MA; Harish K. Malhotra, PhD; Richard C. Russo,
CMD; Leayn Flaherty, BS; Gregory E. Wilding, PhD; Nikhil I. Khushalani, MD; Gary Y. Yang, MD


CXC-Chemokine/CXCR2 Biologic Axis Promotes Angiogenesis In Vitro and In Vivo in Pancreatic Cancer
Yoichi Matsuo, Massimo Raimondo, Timothy A. Woodward, Michael B. Wallace, Kanwar R Gill,
Nobuo Och1, Zhimin Tong, Robert M. Strieter, Robert M. Hoffman, Sushovan Guha


Use of CA 19-9 and CEA to Predict Operability and Survival in Patients With Pancreatic Malignancies
Jay Mehta, Ramkrishna Prabhu, Chetan Kantharia, Avinash Supe


Can CXC-Chemokines and Lipocalin 2 in Exocrine Pancreatic Secretions Distinguish Chronic Pancreatitis From Pancreatic Cancer?
N. Ochi, M. Raimondo, K. Gill2, M.B. Wallace, T.A. Woodward, Y. Matsuo, S. Guha


Gastric Large Cell Neuroendocrine Carcinoma
Tarun Rustagi, MD, Todd J. Alekshun, MD


Zollinger-Ellison Syndrome with Subsequent Association of Insulinoma
arun Rustagi, M1, Robert D. Siegel, MD


Adjuvant Therapy Does Not Improve Survival of Ampullary Carcinoma Patients
Avinash Kumar Tank, Rajneesh Kumar Singh, Anand Prakash, Anu Behari, Ashok Kumar, Rajan Saxena, Vinay Kumar Kapoor


Intensity-Modulated Radiation Therapy Improves the Toxicity Profile of Concurrent Chemoradiation for Upper Abdominal Cancers
Susannah Yovino, Matthew Poppe, Salma Jabbour, Vera David, Michael Garofalo, Naimesh Pandya, Richard Alexander, Nader Hanna, William F. Regine

Advanced Colorectal Cancer

Cost-Effective Chemotherapy Treatment for Advanced Colorectal Cancer
Minsig Choi, MD, Mike Griswold, PhD, Tawfiq Khansur, MD


Inhibition of Epithelial Mesenchymal Transition (EMT) With Immunochemogene Treatment in Metastatic Colorectal Cancer
John Giannios, Emmanuel Michailakis, John Papanikolaou, Nick Alexandropoulos


Detection of K-ras Mutation in Serum DNA of Colon Cancer Patients
Jin Kim, Sung Soo Park, Hyun-Jung Joo, Jae Sook Sung, Kyong Hwa Park, Yeul Hong Kim


Cross-talk Between Notch and Akt/mTOR Signaling in Colon Cancer Cells
Srinivas Koduru, Raj Kumar, Sowmyalakshmi Srinivasan, Chendil Damodaran


Cytotoxicity and Pharmacokinetics of Four Platinum Salts in Human Colon Carcinoma Cell-Line HCT116
Thititip Tippayamontri, Rami Kotb, Léon Sanche, Benoit Paquette

Hepatobiliary Cancer

Liver Transplant for Hepatocellular Carcinoma: Younger Age, Tumor Grade and Pathologic Complete Response to Pre-Transplant Treatment at Time of Surgery Are Best Predictors of Disease-Free Survival
Putao Cen, Alan Cohen, Fatima Anderson, Bob Saggi, Michael Fallon, Victor Machicao, Moises Nevah Rubin, Voon Liaw, Luis Mieles


Intraluminal Brachytherapy as a Palliative Treatment for Inoperable Klatskin Tumor: Case Report
A. Chauhan, P.U. Saxena, S. Charudutt


Temporal Stability of Percutaneously Implanted Coiled Wire Fiducial Markers for Liver IGRT
Valerie M. Gironda, MD; Geoffrey Zhang, PhD; Mark Russell, MS; Vladimir Feygelman, PhD; Junsung Choi, MD; Sarah E. Hoffe, MD


Transcriptional Regulation of Stat3 by TGF-b Signaling in Liver Cancer Cells
Ling Lin1, Kyi Soe, Zhixing Yao, Wilma S. Jogunoori, Lopa Mishra, Aiwu Ruth He


Ruptured Adenosquamous Cell Carcinoma of the Gallbladder
Tarun Rustagi, MD, Mridula Rai, MD, Mohanakrishnan Menon, MD

Adjuvant Colon Cancer

Retrospective Assessment of an Alternative Adjuvant Treatment of Colon Cancer: Oxaliplatin Plus Weekly Bolus 5-Fluorouracil/ Leucovorin
Esther Uña Cidón, Francisco López-Lara

Gastric Cancer

Gene-Modified Cellular Vaccine (GMCV) Transfected with Lipid-Cation Hsp70 Activates Innate and Adaptive Immunity in Primary and Metastatic Gastric Cancer Cells
J. Giannios, E. Michailakis, S. Delis


Stem Cell Therapy With Mesenchymal Stem Cells Induces Apoptosis in Advanced Gastric Adenocarcinoma, and Docetaxel Inhibits Epithelial Mesenchymal Transition
J. Giannios, E. Michailakis, J. Papanikolaou, N. Alexandropulos


Prognosis of Curatively Resected T4 Gastric Cancer: Significance of Combined Resection
Jong-Inn Lee, Jae-Seok Min, Sung-Ho Jin, Jae-Hwan Lee, 1Hye-Jin Kang, 2Sun-Hoo Park,
Ho-Yoon Bang


Conditional Inactivation of Klf4Gene in Distinct Cell Population of Stomach Mucosa Renders Mice Susceptible to Gastric Carcinogenesis
Qiang Li, Li Wang, Zhiliang Jia, Daoyan Wei, Xiangdong Le, Keping Xie


Preoperative Computed Tomography in Gastric Cancer: Does It Work?
Esther Uña, Isabel Jiménez


Nutritional Status After Total Gastrectomy for Gastric Cancer
Esther Uña Cidón


Evaluation of Anti-Cancer Drugs in Advanced and Metastatic Non-Colorectal Gastrointestinal Cancers
Helmy M. Guirgis, MD, PhD


Nigella sativa L Oil Ameliorates Methotrexate-Induced Intestinal Toxicity
Rania M. Labib, Osama A. Badary, Hafez F. Hafez, and Mostafa A.M. Abd El-Hamid


Paraneoplastic Cerebellar Degeneration in Patients With Gastrointestinal Malignancies
Nishant Tageja, MD, Jason Valent, MD, Sachin Gupta, MD